iron accumulation in the eye. Iron contributes to the leading causes of vision loss. Hyperferritinemia means high ferritin in the blood). In hhcs, components of ferritin accumulate in the eye lens and crystalize disrupting the light transmission which enables a person to see. Normally the RPE has ways to prevent iron from entering the retina when iron levels are high, but if iron export from cells is unregulated, iron may accumulate in the eye and degrade the macula. Attachment, posted on Mon, June 20, 2016 by Kayla Wiles. Iron may accumulate to even higher levels in diseased retinas because low oxygen levels (hypoxia) or inflammation can cause cells to retain iron. Age-related macular degeneration (AMD) is regarded as the leading cause of vision loss for people over the age. Dunaiefs research has shown that the oral iron chelator deferiprone may be a possible treatment for AMD if iron accumulation was one of the causes for its development.